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Symbol Name ID |
Hif1a
hypoxia inducible factor 1, alpha subunit MGI:106918 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
impaired macrophage chemotaxis |
abnormal leukocyte migration |
increased susceptibility to induced colitis |
abnormal B cell differentiation |
abnormal T cell differentiation |
abnormal dendritic cell number |
abnormal leukocyte physiology |
abnormal macrophage physiology |
abnormal cytokine level |
increased interferon-gamma secretion |
abnormal interleukin secretion |
decreased interleukin-1 alpha secretion |
abnormal interleukin-1 beta secretion |
decreased interleukin-1 beta secretion |
decreased interleukin-12 secretion |
decreased interleukin-6 secretion |
abnormal tumor necrosis factor secretion |
decreased tumor necrosis factor secretion |
increased tumor necrosis factor secretion |
decreased susceptibility to induced arthritis |
decreased susceptibility to endotoxin shock |
decreased inflammatory response |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Hif1atm1Kats/Hif1atm1Kats | ||||||||||||||||||||||||
| Hif1atm3Rsjo/Hif1atm3Rsjo Tg(Lck-cre)1Jtak/0 (conditional) |
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| Hif1atm3Rsjo/Hif1atm3Rsjo Ndor1Tg(UBC-cre/ERT2)1Ejb/0 (conditional) |
* | |||||||||||||||||||||||
| Hif1atm3Rsjo/Hif1atm3Rsjo Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Hif1atm3Rsjo/Hif1atm3Rsjo Tg(Fabp1-cre)1Jig/0 (conditional) |
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| Hif1atm3Rsjo/Hif1atm3Rsjo Tg(Tal1-cre/ERT)42-056Jrg/0 (conditional) |
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| Ccl17tm2.1(cre)Ifo/Ccl17+ Hif1atm3Rsjo/Hif1atm3Rsjo (conditional) |
* | |||||||||||||||||||||||
| Hif1atm3Rsjo/Hif1atm3Rsjo Tg(Itgax-cre)1-1Reiz/0 (conditional) |
* | |||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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